Delta-Fraction Tocotrienols 50
Delta-Fraction Tocotrienols 50, 75 Softgels by NUTRICOLOGY | 713947552708
Delta-Fraction Tocotrienols contains delta- and gamma-tocotrienols. Along with tocopherols, tocotrienols are part of the vitamin E family. They are important oil-soluble antioxidants, crucial to the protection of fats, oils, and cell membranes against free radical damage. Free radicals are reactive oxygen compounds generated by our normal biological processes and by exposure to ultraviolet radiation, pollution, cigarette smoke and other environmental and biological stress factors. High levels of free radicals can break down cell membranes and damage cell DNA.
Tocotrienols have been shown to strengthen arterial walls, and to support blood flow through arteries (coronary, carotid, and peripheral). Tocotrienols help prevent the oxidation of LDL cholesterol, and some studies suggest that tocotrienols may prevent cholesterol oxidation more effectively than tocopherols. Unlike tocopherols, delta- and gamma-tocotrienols also support healthy levels of cholesterol, including total and LDL cholesterol. Tocotrienols have an inhibitory effect on HMG-CoA reductase, the liver enzyme that is critical to the rate at which cholesterol is synthesized.
Tocotrienols may potentially support endothelial functions and overall cardiovascular health in other ways, including supporting healthy levels of thromboxane, adhesion molecules, and C-reactive protein (CRP), and healthy platelet aggregation. Tocotrienols do not lower plasma coenzyme Q10 as do the statin drugs, but instead increase it.
Preliminary research suggests that delta-tocotrienol has potential to support healthy metabolism by enhancing insulin function, including insulin sensitivity. Research also suggests that tocotrienols may offer some protection from the sun's ultraviolet radiation, working synergistically with tocopherols and helping preserve tocopherols in skin cells.
A small structural difference between tocopherols and tocotrienols results in distinct functional differences in their antioxidant activities, probably due to differences in how each is incorporated into cellular membranes. Tocopherols, with a saturated side chain that interacts hydrophobically with acyl side chains of membrane phospholipids, are relatively less able to access lipid radicals due to steric hindrance. Tocotrienols, with an unsaturated farnesyl side chain, have increased accessibility to lipid radicals and resulting greater antioxidant capacity. Tocopherols also have a significantly longer tail, so they anchor deeply into lipid membranes, whereas tocotrienols anchor less deeply, allowing them to cross more easily from one membrane to the next. These factors may explain why tocotrienol is 40-60 times more powerful as an antioxidant than tocopherol.
Tocotrienols occur in many of the same sources as tocopherols, such as oil from rice bran, palm fruit, barley, and wheat germ, and both tocopherols and tocotrienols occur in alpha, beta, gamma, and delta fractions. Palm and rice contain large amounts of tocopherols and only minor amounts of active delta-tocotrienol, so Delta-Fraction Tocotrienols utilizes tocotrienols extracted from annatto. Annatto produces a superior form of tocotrienols, high in the most beneficial fractions, delta-tocotrienol and gamma-tocotrienol, and is free of tocopherols.
Tocotrienols are well tolerated, with an extensive history of study and safe use. Human consumption of 240 mg/day of tocotrienols for up to two years caused no adverse effects, and animal toxicity studies suggest that they are safe at much higher levels.
As a dietary supplement, 1 or 2 softgels one or two times daily with meals, or as directed by a healthcare practitioner.
Keep in a cool, dry place, tightly capped.